The study of mRNA expression profiles of main cell function regulator genes in unchanged colonic mucosa from healthy donors

A comparative analysis of molecular genetic phenotypes mucous membrane cells in five anatomical regions the colon a group healthy donors was conducted by comparing mRNA expression profiles 62 genes involved regulation vital cellular function. We used 181 biopsy samples morphologically unchanged colonic mucosa, obtained from (ascending, transverse-colon, descending, sigmoid) and rectum sections during prophylactic colonoscopy 58 with no pathology. The levels for apoptosis, proliferation, transcription, differentiation, cell-cell adhesion, immune response were assessed RT-PCR. Statistically significant differences found colon. results study can serve as basis creating reference database (values profiles), developing methods differential diagnostics screening various pathologies